Frågedatum: 1988-12-11
RELIS database 1988; id.nr. 6166, DRUGLINE
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A pregnant woman (7 weeks) received Postafen (meclozine) 1-3 tablet per day, for treating vomiting



Fråga: A pregnant woman (7 weeks) received Postafen (meclozine) 1-3 tablet per day, for treating vomiting and nausea. Is there any risk for foetus malformation?

Sammanfattning: Meclozine, as most of the antihistamines, is considered to be safe and useful for treating vomiting of pregnancy.

Svar: A similar question has been previously answered in the Drug Information Centre (1) and there is support (2-3) for lack of teratogenic effect by the drug. At least three studies involving large numbers of patients have concluded that meclozine is not a human teratogen (2).

Most of the cases of vomiting during pregnancy can be managed without drug treatments. Small frequent carbohydrate meals, as well as avoidance of fatty and greasy foods. In those cases in which a more serious alteration is present, antihistamines are considered safe as a first-choice drug (4-8).

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